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Analytical Capabilities We use a range of advanced analytical tools during our day-to-day work. Whether for contract R&D product development , problem solving projects or defined materials analysis requests, we always provide full interpretation of the results. We operate both chemical and physical analytical tools including: Thermal spectroscopy: TGA, DSC Light spectroscopy: UV-Vis, FTIR Chromatography: High-performance liquid chromatography (HPLC) Rheometer (rotational shear): elastic and viscoelastic flow characterization, static and dynamic states, Thixotropic behaviour analysis Viscosity (Brookfield): spindle test Loss on Dry (LoD), Lyophilization (freeze drying) Mechanical: tensile test (Instron) Electric: 4-point probe sheet resistance We also have direct access to additional analytical tools such scanning electron microscope (SEM), ICP, NMR and others. Contact us to learn more MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us MEET THE TEAM Dr. Steve Daren President & Founder Dr. Shai Garty R&D Project Leader Dr. Anna Munder R&D Project Leader Sagi Daren Chief Business Officer Vlada Nikolayevsky (MSc.) R&D Chemist & Lab Manager Pavel Basin (MSc.) R&D Chemist Ofra Cohen Bookkeeper

Materials Experts Materials Experts Home Services The Team Accessibility Statement Verticals Testimonials Contact Us More Download PDF Differential Scanning Calorimetry (DSC 6000 – Perkin Elmer) The differential scanning calorimeter (DSC) is a fundamental tool in thermal analysis. The information these instruments generate is used to understand amorphous and crystalline behavior, polymorph and eutectic transitions, curing and degree of cure, and many other material properties used to design, manufacture, and test products. It can be used in many industries – from pharmaceuticals and polymers, to nanomaterials and agrifood products. DSC analysis is used to measure melting temperature, heat of fusion, latent heat of melting, reaction energy and temperature, glass transition temperature, crystalline phase transition temperature and energy, precipitation energy and temperature, denaturation temperatures, oxidation induction times, and specific heat or heat capacity. By measuring the amount of energy absorbed or released by non-corrosive sample when it is heated or cooled, DSC analysis provide quantitative and qualitative data on endothermic (heat absorption) and exothermic (heat evolution) processes. Thermogravimetric analysis or thermal gravimetric analysis (TGA 8000– Perkin Elmer) Thermogravimetry Analysis (TGA) is the technology for measuring the relationship between mass and temperature (or time), under heating or cooling process, or under constant temperature, while the temperature is under control. TGA measures weight/mass change (loss or gain) and the rate of weight change as a function of temperature, time and atmosphere. Measurements are used primarily to determine the composition of materials and to predict their thermal stability. The technique can characterize materials that exhibit weight loss or gain due to sorption/desorption of volatiles, decomposition, oxidation and reduction. Mechanisms of Weight Change in TGA 1 Weight Loss: Decomposition: The breaking apart of chemical bonds. Evaporation: The loss of volatiles with elevated temperature. Reduction: Interaction of sample to a reducing atmosphere (hydrogen, ammonia, etc.). Desorption. 2 Weight Gain: Oxidation: Interaction of the sample with an oxidizing atmosphere. Absorption. All of these are kinetic processes (i.e. there is a rate at which they occur). Example: Characterization of Polymers Using TGA W.J. Sichina, Marketing Manager – Washinton dep.edu • Compositional analysis of multi-component materials or blends • Thermal stabilities • Oxidative stabilities • Estimation of product lifetimes • Decomposition kinetics • Effects of reactive atmospheres on materials • Filler content of materials • Moisture and volatiles content Other currents applications: Ceramics, Metal Materials, Flame Retardant, Carbon capture, Chemical loop, Vegetable Oil Oxidative Stability, Polymer Applications, and others Download PDF Spectrum obtained can be analysis compare We can analyze following type of samples Soft polymers, Rubbers, thin film* Soft powders, Pastes, Gels, Aqueous solutions Surface coatings Organic products Proteins and other biochemical Comparison of plant extract. Impurity included a pure reference sample. Fourier transform infrared spectroscopy (FTIR ) FTIR is characterization technique used in qualitative material analysis within the biological, biomedical and chemical industry; this technique takes advantage of the vibrational transitions of a molecule and is widely used in organic synthesis, polymer science, petrochemical engineering, pharmaceutical industry and food analysis. FTIR is a method of measuring infrared absorption and emission spectra. In organic or inorganic compounds, IR Spectroscopy is used for checking presence of functional groups. The fundamental measurement obtained in infrared spectroscopy is an infrared spectrum, which is a plot of measured infrared intensity versus wavelength (or frequency) of light. Units of cm-1 is commonly used for wavenumber. *By transmission, analyzing of Thin Films* should be in the freestanding condition and thickness should be ≤ 50μm. Thicker film can be analyzed By ATR Attenuated total reflection (ATR) spectroscopy ATR is one accessory of FTIR spectrophotometer to measure surface properties of solid or thin film samples rather than their bulk properties. Generally, ATR has a penetration depth of around 1 or 2 micrometers depending on your sample conditions. The infrared radiation interacts with the sample through series of standing waves called evanescent waves, which penetrate the sample at each reflection point. An evanescent wave is produced each time the infrared beam is reflected from the inside surface of the crystal. Some of the energy of evanescent wave is absorbed by the sample and reflected radiation is returned to the detector. Link to website Download PDF Fourier transform infrared spectroscopy (FTIR ) The technique is based on absorption of light. In molecular absorbance spectroscopy, a beam of ultraviolet or visible light is directed through a sample. Some of the light may be transmitted through the sample. Instrument measures transmitted light. Light that was not transmitted through the sample was absorbed. Absorbance (A) is defined as -log(P/Po). Beer Lambert Law States that absorbance of electromagnetic radiation by a given species is directly proportional to the concentration of the analyte. It is expressed as: A= εbC • where A is the absorbance, ε is the molar absorptivity, b is the path length and C is the concentration of analyte. Because ε and b are fixed under experimental conditions, the result is a linear relationship between absorbance and concentration. Download PDF Viscometer DV-II Brookfield The Brookfield DV-II+Pro Viscometer measures fluid viscosity at given shear rates. Viscosity is a measure of a fluid’s resistance to flow. The Viscometer rotates a sensing element in a fluid and measures the torque necessary to overcome the viscous resistance to the induced movement. This is accomplished by driving the immersed element, which is called a spindle, through a beryllium copper spring. The degree to which the spring is wound, indicated by the red pointer, is proportional to the viscosity of the fluid. All units of measurement are calculated in units of centipoise (cP); SI: 1 cP = 1 mPa•s Loss on Drying (LOD) A method commonly used for moisture content determination is the loss-on-drying method. Occasionally it may refer to the loss of any volatile matter from the sample. Download PDF Freeze dryer or Lyophilizer Lyophilizer and freeze dryer are synonymous names for the same equipment. A lyophilizer executes a water removal process typically used to preserve perishable materials, to extend shelf life or make the material more convenient for transport. Lyophilizers work by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to sublimate. Controlled freeze-drying keeps the product temperature low enough during the process to avoid changes in the dried product appearance and characteristics. It is an excellent method for preserving a wide variety of heat-sensitive materials such as proteins, microbes, pharmaceuticals, tissues & plasma. High-performance liquid chromatography (HPLC) High performance liquid chromatography or commonly known as HPLC is an analytical technique used to separate, identify or quantify each component in a mixture. HPLC works following the basic principle of thin layer chromatography or column chromatography, where it has a stationary phase and a mobile phase. The mobile phase flows through the stationary phase and carries the components of the mixture with it. The mixture is separated and then identified and quantified by spectroscopy. A computer analyzes the data show the output in display.

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us Production & Scale-up Together with our contract R&D services, we also offer our clients scale-up and production services. Our capabilities and experience allow us to take production projects of batches in the kilogram range. Such services are suitable for either: Start up companies scaling up volumes during go-to-market stage (beta testing volumes) Veteran companies in need for custom chemicals at limited quantities (specialty chemicals) Examples for some of the chemicals we produce for our clients include: Photo-chromic coating, optical adhesives, PVC solutions for graphic arts, buffers for medical applications, fluorescent dies for plastic industry, polymers for composite materials, CBD formulations, nano-clays for water treatments and many others. Once produced, the products undergo chemical analysis according to customer requirements. Contact us to learn more

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us Pharma Developing a new innovative drug takes years and is often done collaboration with various contract development and manufacturing organizations (CDMO) partners. While not defined as CDMO, Daren Labs has supported many companies develop new drugs formulations during their pre-clinical stages, when pharma qualifications are less relevant and GLP isn’t yet required. Working with us at pre-clinical stages enables fast development cycles, screening of multiple combinations, at absolute discretion, locally. Among the services we provide are literature surveys, screening of materials, HPLC/LCMS method development, analysis and separations of functional groups in Cannabis and other plant-based derivative, raw materials validations and more. Contact us to learn more

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us Food Tech Foods, whether natural or engineered, are complex chemical systems composed of various material families including fats, proteins, sugars, minerals and more. Moreover, foods undergo multiple physical and chemical processing before they are catered. Developing new food technologies is a huge challenge that required strong understanding of such materials and processes as well as relevant analytical skills and equipment. We can help you develop your new food products and provide you an objective, data-based outlook of your product, addressing topics such as: composition and water content, smell, texture, optimal storage and cooking conditions and much more. Serving some of the most prominent food tech companies in Israel today, we have gained significant experience and knowledge that can help you make you next leap forward. Contact us to learn more

YEARS OF HANDS-ON EXPERIENCE MAKE DAREN LABS A LEADER IN SYNTHESIS AND FORMULATION DEVELOPMENT Chemistry Lab Services SYNTHESIS & FORMULATION Over the years we have gained extensive experience in developing custom synthesis and formulations for a wide range of materials in diverse applications. Whether you have a reference material or spec you would like to duplicate or a set of properties you would like to tailor/reverse engineer - our chemists can do it. Among the materials and formulations we’ve developed in the past are: pharmaceuticals, membranes, coatings, flame retardants, optical and bio polymers, adhesives, dental implants, chemical sensors and bio-active materials. We can also help you scale up the processes as well as provide small-scale (gram to kilo) production of the developed materials. Our team can work hand-in-hand with you or lead a full scale project solution – according to your client. Why invest in building R&D capabilities when you can have our team of experts develop new strategic materials or formulations for you, faster, cheaper and discreetly with no IP claims? Book a space Synthesis & Formulation

We Give Back Daren Labs helps the show producers and actors to design new exciting experiments which will later be presented in numerous shows around the world. We do this voluntarily, with the future of children and science in mind. Children are our future, and at Daren Labs we decided we would like to share with children our community knowledge, curiosity and passion for science, encouraging them to follow our steps. In order to do this effectively, we have partnered with Dr. Molecula (Molecule in Hebrew) an entertaining and funny science show for all ages performing in many location worldwide.

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us Contract R&D Subcontracting your R&D projects isn’t an easy decision to make. However, with the right partner contract R&D can be a cost-effective way to get results, faster. Our team of experts leads dozens of materials-development project annually, working closely with our clients, making sure results meet the goal. Our long-year diverse experience, in-house lab infrastructure and analytics, allow us to develop custom solutions efficiently. In cases of specialty materials development, we are also able to manufacturer the developed product (kilo scale batches). Some contract R&D projects we can mention: Development of polymeric membrane for flexible batteries (technology commercialized). Developed cross-linking procedures for hyaluronic acid hydrogels Developed and scaled up a five-stage synthesis of a new steroid drug for Fatty Liver Disease (now in phase III trials) Reverse engineering and pilot production of a bio-degradable polymer for orthopedic implants. Development of UV sensitive photochromic coating for optical equipment. Daren labs produces this material for the OEM. Developed an acrylic surface coating that enhances the shelf-life of cut flowers (technology commercialized). Contact us to learn more

MATERIALS EXPERTS Materials Experts Home Services Contract R&D Scale up & Production Problem Solving Expert Opinion Analytical Capabilities DaaS Tech Scouting The Team Accessibility Statement Verticals Food Tech Energy and Cleantech Pharma Alternative Proteins Medical Devices Traditional Industries Testimonials Client Portfolio Contact Us Energy and Cleantech New energy sources, storage and sustainable technologies often pose significant challenges related to materials. Whether in new battery cells, bio-fuels, carbon capturing or bio-plastic technologies, materials are always in the core of the development and require relevant expertise. During the years we supported the development of multiple new clean technologies, many times from very early stages. Contact us to learn how we can help you develop your new venture, making our world cleaner and healthier. Contact us to learn more

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